The Institutional Animal Care and Use Committee (IACUC) is required by federal regulations for institutions that use animals in research, teaching, and testing. The IACUC oversees the review and approval of animal use activities and inspection of spaces where live animal work occurs.
This LibGuide provides access to an array of information and resources that support researchers in conducting and adhering to literature search requirements for their IACUC protocol. If you have a resource suggestion to add to this guide, please do not hesitate to contact Marina Chilov, Research Informationist or Donna Gibson, Director, Library Services.
Federal regulations prohibit unnecessary duplication of studies involving animals. By conducting a literature search, researchers may discover that other laboratories or colleagues have already worked on similar research, making running a duplicate experiment unnecessary. They may also discover alternatives to the use of animals, alternative (and possibly more humane) methods of animal care, treatment, or experimental design that requires fewer animals.
MSK Researchers can connect with their library to ensure that a comprehensive search is completed, saving them time and money. MSK Researchers can submit their question online or view the Ask Us page to see all available communication options. If submitting an online literature search, please note the "How can we help?" field and select "Submit a literature or PICO(T) search request."
The Animal Welfare Act requires the principal investigator (PI) to examine alternatives to potentially painful procedures. The USDA's Animal Care Resource Guide provides more in depth guidance as to how best to meet this requirement.
Policy Number 12 (Consideration of Alternatives to Painful/Distressful Procedures) this guide specifically outlines the requirements for conducting and reporting the results of a comprehensive literature search. The researcher should include the following information in the report:
Part of developing your search strategy is thinking about the three Rs and asking targeted questions to address the study protocol.