COVID Impacts

Yelin D, Moschopoulos CD, Margalit I, Gkrania-Klotsas E, Landi F, Stahl JP, Yahav D. ESCMID rapid guidelines for assessment and management of long COVID. Clin Microbiol Infect. 2022 Jul;28(7):955-972.

Veronese N, Bonica R, Cotugno S, Tulone O, Camporeale M, Smith L, Trott M, Bruyere O, Mirarchi L, Rizzo G, Bavaro DF, Barbagallo M, Dominguez LJ, Marotta C, Silenzi A, Nicastri E, Saracino A, Di Gennaro F. Interventions for Improving Long COVID-19 Symptomatology: A Systematic Review. Viruses. 2022 Aug 24;14(9):1863.

Zeraatkar D, Ling M, Kirsh S, Jassal T, Shahab M, Movahed H, Talukdar JR, Walch A, Chakraborty S, Turner T, Turkstra L, McIntyre RS, Izcovich A, Mbuagbaw L, Agoritsas T, Flottorp SA, Garner P, Pitre T, Couban RJ, Busse JW. Interventions for the management of long covid (post-covid condition): living systematic review. BMJ. 2024 Nov 27;387:e081318.

Dietz TK, Brondstater KN. Long COVID management: a mini review of current recommendations and underutilized modalities. Front Med (Lausanne). 2024 Jun 14;11:1430444.

Seo JW, Kim SE, Kim Y, Kim EJ, Kim T, Kim T, Lee SH, Lee E, Lee J, Seo YB, Jeong YH, Jung YH, Choi YJ, Song JY. Updated Clinical Practice Guidelines for the Diagnosis and Management of Long COVID. Infect Chemother. 2024 Mar;56(1):122-157.

Ashraf N, Abou Shaar B, Taha RM, Arabi TZ, Sabbah BN, Alkodaymi MS, Omrani OA, Makhzoum T, Almahfoudh NE, Al-Hammad QA, Hejazi W, Obeidat Y, Osman N, Al-Kattan KM, Berbari EF, Tleyjeh IM. A systematic review of trials currently investigating therapeutic modalities for post-acute COVID-19 syndrome and registered on WHO International Clinical Trials Platform. Clin Microbiol Infect. 2023 May;29(5):570-577.

Chee YJ, Fan BE, Young BE, Dalan R, Lye DC. Clinical trials on the pharmacological treatment of long COVID: A systematic review. J Med Virol. 2023 Jan;95(1):e28289.

Choi YJ, Seo YB, Seo JW, Lee J, Nham E, Seong H, Yoon JG, Noh JY, Cheong HJ, Kim WJ, Kim EJ, Song JY. Effectiveness of Antiviral Therapy on Long COVID: A Systematic Review and Meta-Analysis. J Clin Med. 2023 Nov 28;12(23):7375.

Rubin R. The Latest Research About Paxlovid: Effectiveness, Access, and Possible Long COVID Benefits. JAMA. 2024 Oct 1;332(13):1040-1042.

Geng LN, Bonilla H, Hedlin H, Jacobson KB, Tian L, Jagannathan P, Yang PC, Subramanian AK, Liang JW, Shen S, Deng Y, Shaw BJ, Botzheim B, Desai M, Pathak D, Jazayeri Y, Thai D, O'Donnell A, Mohaptra S, Leang Z, Reynolds GZM, Brooks EF, Bhatt AS, Shafer RW, Miglis MG, Quach T, Tiwari A, Banerjee A, Lopez RN, De Jesus M, Charnas LR, Utz PJ, Singh U. Nirmatrelvir-Ritonavir and Symptoms in Adults With Postacute Sequelae of SARS-CoV-2 Infection: The STOP-PASC Randomized Clinical Trial. JAMA Intern Med. 2024 Sep 1;184(9):1024-1034.

Krumholz HM, Sawano M, Bhattacharjee B, Caraballo C, Khera R, Li SX, Herrin J, Coppi A, Holub J, Henriquez Y, Johnson MA, Goddard TB, Rocco E, Hummel AC, Al Mouslmani M, Putrino DF, Carr KD, Carvajal-Gonzalez S, Charnas L, De Jesus M, Ziegler FW 3rd, Iwasaki A. The PAX LC Trial: A Decentralized, Phase 2, Randomized, Double-Blind Study of Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir for Long COVID. Am J Med. 2025 May;138(5):884-892.e4.

McCarthy MW. Paxlovid as a potential treatment for long COVID. Expert Opin Pharmacother. 2023 Sep-Dec;24(17):1839-1843.

Livieratos A, Gogos C, Akinosoglou K. Beyond Antivirals: Alternative Therapies for Long COVID. Viruses. 2024 Nov 19;16(11):1795.

Wu BQ, Liu DY, Shen TC, Lai YR, Yu TL, Hsu HL, Lee HM, Liao WC, Hsia TC. Effects of Hyperbaric Oxygen Therapy on Long COVID: A Systematic Review. Life (Basel). 2024 Mar 26;14(4):438.

Kjellberg A, Hassler A, Boström E, El Gharbi S, Al-Ezerjawi S, Kowalski J, Rodriguez-Wallberg KA, Bruchfeld J, Ståhlberg M, Nygren-Bonnier M, Runold M, Lindholm P. Hyperbaric oxygen therapy for long COVID (HOT-LoCO), an interim safety report from a randomised controlled trial. BMC Infect Dis. 2023 Jan 20;23(1):33.

Hadanny A, Zilberman-Itskovich S, Catalogna M, Elman-Shina K, Lang E, Finci S, Polak N, Shorer R, Parag Y, Efrati S. Long term outcomes of hyperbaric oxygen therapy in post covid condition: longitudinal follow-up of a randomized controlled trial. Sci Rep. 2024 Feb 15;14(1):3604.

Markser A, Vöckel J, Schneider A, Baumeister-Lingens L, Sigrist C, Koenig J. Non-Invasive Brain Stimulation for Post-COVID-19 Conditions: A Systematic Review. Am J Med. 2025 Apr;138(4):681-697.

Chandan JS, Brown KR, Simms-Williams N, Bashir NZ, Camaradou J, Heining D, Turner GM, Rivera SC, Hotham R, Minhas S, Nirantharakumar K, Sivan M, Khunti K, Raindi D, Marwaha S, Hughes SE, McMullan C, Marshall T, Calvert MJ, Haroon S, Aiyegbusi OL; TLC Study. Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review. Int J Environ Res Public Health. 2023 Feb 16;20(4):3477.

Romanet C, Wormser J, Cachanado M, Santiago MG, Chatellier G, Valenza MC, Philippart F. Effectiveness of physiotherapy modalities on persisting dyspnoea in long COVID: A systematic review and meta-analysis. Respir Med. 2025 Jan;236:107909. doi: 10.1016/j.rmed.2024.107909.

Pollini E, Lazzarini SG, Cordani C, Del Furia MJ, Kiekens C, Negrini S, Arienti C. Effectiveness of Rehabilitation Interventions on Adults With COVID-19 and Post-COVID-19 Condition. A Systematic Review With Meta-analysis. Arch Phys Med Rehabil. 2024 Jan;105(1):138-149.

Zheng C, Chen XK, Sit CH, Liang X, Li MH, Ma AC, Wong SH. Effect of Physical Exercise-Based Rehabilitation on Long COVID: A Systematic Review and Meta-analysis. Med Sci Sports Exerc. 2024 Jan 1;56(1):143-154.

Oliveira MR, Hoffman M, Jones AW, Holland AE, Borghi-Silva A. Effect of Pulmonary Rehabilitation on Exercise Capacity, Dyspnea, Fatigue, and Peripheral Muscle Strength in Patients With Post-COVID-19 Syndrome: A Systematic Review and Meta-analysis. Arch Phys Med Rehabil. 2024 Aug;105(8):1559-1570.

Deng J, Qin C, Lee M, Lee Y, You M, Liu J. Effects of rehabilitation interventions for old adults with long COVID: A systematic review and meta-analysis of randomised controlled trials. J Glob Health. 2024 Sep 6;14:05025.

Sánchez-García JC, Reinoso-Cobo A, Piqueras-Sola B, Cortés-Martín J, Menor-Rodríguez MJ, Alabau-Dasi R, Rodríguez-Blanque R. Long COVID and Physical Therapy: A Systematic Review. Diseases. 2023 Nov 9;11(4):163.

Pouliopoulou DV, Macdermid JC, Saunders E, Peters S, Brunton L, Miller E, Quinn KL, Pereira TV, Bobos P. Rehabilitation Interventions for Physical Capacity and Quality of Life in Adults With Post-COVID-19 Condition: A Systematic Review and Meta-Analysis. JAMA Netw Open. 2023 Sep 5;6(9):e2333838.

Fugazzaro S, Contri A, Esseroukh O, Kaleci S, Croci S, Massari M, Facciolongo NC, Besutti G, Iori M, Salvarani C, Costi S; Reggio Emilia COVID-19 Working Group. Rehabilitation Interventions for Post-Acute COVID-19 Syndrome: A Systematic Review. Int J Environ Res Public Health. 2022 Apr 24;19(9):5185.

Marshall-Andon T, Walsh S, Berger-Gillam T, Pari AAA. Systematic review of post-COVID-19 syndrome rehabilitation guidelines. Integr Healthc J. 2023 Feb 14;4(1):e000100.

Yang J, Lim KH, Lim KT, Woods JT, Mohabbat AB, Wahner-Roedler DL, Ganesh R, Bauer BA. Complementary and alternative medicine for long COVID: a systematic review of randomized controlled trials. Ther Adv Chronic Dis. 2023 Oct 11;14:20406223231204727.

Ranisavljev M, Stajer V, Todorovic N, Ostojic J, Cvejic JH, Steinert RE, Ostojic SM. The effects of 3-month supplementation with synbiotic on patient-reported outcomes, exercise tolerance, and brain and muscle metabolism in adult patients with post-COVID-19 chronic fatigue syndrome (STOP-FATIGUE): a randomized Placebo-controlled clinical trial. Eur J Nutr. 2024 Nov 26;64(1):28. doi: 10.1007/s00394-024-03546-0. Erratum in: Eur J Nutr. 2025 Feb 1;64(2):80.

Pang W, Yang F, Zhao Y, Dai E, Feng J, Huang Y, Guo Y, Zhou S, Huang M, Zheng W, Ma J, Li H, Li Q, Hou L, Zhang S, Wang H, Liu Q, Zhang B, Zhang J. Qingjin Yiqi granules for post-COVID-19 condition: A randomized clinical trial. J Evid Based Med. 2022 Mar;15(1):30-38.