You can install an instance of cBioPortal using the code and documentation on GitHub, which is available under a Affero GPL V3 license. The frontend and backend have separate GitHub repositories. The full installation consists of the following components: 

• backend
  • MySQL database
  • REST API written in Java Spring
  • Redis cache for storing frequently used queries (optional)
• validator checks file formats before importing data into the database
• frontend built with React, Mobx and Bootstrap
• session service for storing user saved data such as virtual studies and groups
  • REST API written in Java Spring enabling retrieval and writing to the database
  • MongoDB database
• cBioPortal also uses the APIs from various external services to provide more information about a variant

Installing a local version of cBioPortal requires system administration skills, such as installing and configuring Tomcat and MySQL. Consult the GitHub repositories and documentation for more assistance; however, the cBioPortal team does not have the capacity to offer technical support beyond the existing public documentation. 

You can suggest your datasets for curation by contacting cBioPortal administration. All data featured on cBioPortal is completely public and clinical data must be de-identified. 

You can view the list of datasets currently submitted for consideration at cBioPortal's DataHub. cBioPortal also actively curates datasets from the literature, curated from the data published with the manuscripts. Admin occasionally reaches out to investigators to acquire additional data, such as clinical attributes. All mutation calls (in VCF or MAF format) are processed through an internal pipeline to annotate the variant effects in a consistent way across studies.

cBioPortal suggests three additional web-based tools for data analysis and visualization:

• OncoPrinter: a tool for generating oncoprints and performing mutual exclusivity analysis from your own data. Input genomic alteration, clinical, or heatmap data to generate a print. 
• MutationMapper: a tool for interpreting mutations with protein annotations. Input tab-delimited or space-delimited mutation data and select a reference gene. Read more about data formatting guidelines and view example data on the MutationMapper site.  
• AVM for cBioPortal (maintained by Aqumin Medical, available for Windows users): Windows software that loads data into 3D Landscapes for interactive visualization and pathway analysis. Use your own data, or test it out with cBioPortal's current datasets.